The Neglected Diseases Section in PLoS Medicine: Moving Beyond Tropical Infections

Since our launch in October 2004, PLoS Medicine has published a policy and review section dedicated to neglected diseases. Its focus has been on the chronic tropical infections, mostly parasitic and bacterial, that burden the world’s poorest people and that are also a major cause of global poverty. The many ways in which these diseases have been sidelined are well documented [1], and our main aim for the section was to help to place these conditions in the limelight. So what has the section achieved, and where is it heading next, particularly now that PLoS has launched a journal dedicated to the neglected tropical diseases (NTDs; http://www.plosntds.org/)? The 21 articles published to date give a broad-ranging overview of the landscape of NTDs. Each article focused either on the global campaign to tackle a specific disease, such as trachoma or Buruli ulcer, or on a new strategy for approaching neglected diseases in general, including innovative ways of designing, developing, and funding antiparasitic drugs (see Text S1). Many of these articles have challenged the widespread sense of hopelessness surrounding the NTDs. Mary Moran’s analysis [2], for example, found that 63 neglecteddisease drug projects were under way at the end of 2004, three-quarters of which are being conducted by public–private partnerships, often involving multinational or small-scale pharmaceutical firms. As we have written before, we are witnessing “a new era of hope for the world’s most neglected diseases” [3]. The Neglected Diseases section has arguably had an impact upon the wider global health community, for example among policy makers and funding agencies. Two articles in particular stand out for their international influence. The first, by David Molyneux, Peter Hotez, and Alan Fenwick, presented the case for integrating the control of NTDs in Africa by scaling up a “rapid-impact package” of four antimicrobial drugs that have synergistic actions on multiple diseases [4]. This package, argued the authors, could tackle seven NTDs (schistosomiasis, trachoma, lymphatic filariasis, onchocerciasis, hookworm, trichuriasis, and ascariasis) at an annual cost of only about $US0.40 per person. The authors’ follow-up article discussed the many opportunities for integrating NTD control with that of the “big three” diseases: HIV, malaria, and tuberculosis [5]. The first of these two articles led to a United Kingdom parliamentary question, by Member of Parliament Nicholas Soames, about the UK’s funding of parasitic diseases [6], while the second helped make the case for a United Nations mandate to incorporate NTD control into its campaign to roll back malaria [7]. Both papers laid the foundation for the creation of a new global nonprofit organization, the Global Network for Neglected Tropical Disease Control (GNNTDC, http:// gnntdc.sabin.org/). And the idea of integrated control, laid out in the two papers, has gained traction in the donor community—the United States Agency for International Development, for example, awarded a $US100 million grant to RTI International to scale up integrated control of NTDs in Africa [8], while Geneva Global Inc. awarded the GNNTDC US$8.9 million to deliver the “rapid-impact package” in Rwanda and Burundi [9]. PLoS Medicine’s Neglected Diseases section was also the catalyst for the launch of the world’s first open-access journal specifically devoted to the NTDs. In 2005, the section caught the attention of Professor Peter Hotez at George Washington University and the Sabin Vaccine Institute, who proposed to PLoS that we launch PLoS Neglected Tropical Diseases. One of us (GY) presented the idea at the World Health Organization’s (WHO’s) “Strategic and technical meeting on intensified control of neglected tropical diseases” in Berlin in April 2005 [10], which led to the WHO’s Department of Neglected Tropical Diseases giving the proposal its formal support. The momentum continued to build— several global leaders in NTDs agreed to serve on the journal’s editorial board, and the Bill & Melinda Gates Foundation awarded PLoS a $US1.1 million grant to cover the journal’s launch phase. PLoS Neglected Tropical Diseases— which publishes research, commentary, analysis, and reviews on the pathology, epidemiology, treatment, control, and prevention of the NTDs—launched at the end of October 2007. Its arrival was heralded in the New York Times (November 6, 2007) with the headline “Shining Light on Diseases Often in the Shadows” [11], while an editorial in The Lancet about the new journal praised the “investment in scaling up communication about global health” [12]. The journal publishes the broadest range of NTDs research in a single open-access venue, while its Magazine section advocates for those who suffer from the plight of these tropical infections. Built upon an online publishing platform called Topaz (see http://www.plos.org/cms/ node/36/), the journal takes advantage of the latest “Web 2.0” tools from The Neglected Diseases Section in PLoS Medicine: Moving Beyond Tropical Infections